WebMar 24, 2024 · Alendronate is FDA-approved for the treatment of postmenopausal osteoporosis, prevention of postmenopausal osteoporosis, steroid-induced osteoporosis, male osteoporosis, and Paget disease of the bone. Alendronate is an option for maintaining or increasing bone mass, although risedronate is the preferred agent in men with … WebJan 5, 1999 · Alendronate inhibition of bone resorption in mouse calvaria also is blocked by mevalonate whereas clodronate inhibition is not. Furthermore, rabbit osteoclast formation and activity also are inhibited by lovastatin and alendronate. The lovastatin effects are prevented by mevalonate or geranylgeraniol, and alendronate effects are prevented by ...
Alendronate Side Effects, Dosage, Uses & More
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WebFeb 1, 2024 · It should be taken as soon as you get out of bed in the morning and at least 30 minutes before any food, beverage, or other medicines. Food and beverages (eg, mineral water, coffee, tea, or juice) will decrease the amount of alendronate absorbed by the body. Waiting longer than 30 minutes will allow more of the drug to be absorbed. WebAug 27, 2024 · Skin blisters. Swelling of the face, tongue, or throat. Postmarketing side effects of alendronate reported include: Body as a whole: Hypersensitivity reactions including hives and skin swelling; transient muscle pain, feeling unwell ( malaise ), weakness/lack of energy, and fever; symptomatic hypocalcemia; swelling of extremities. WebAlendronate treatment results in an early and dose-dependent inhibition of skeletal resorption, which can be followed clinically with biochemical markers, and which ultimately reaches a plateau and is slowly reversible upon discontinuation of the drug. These findings reflect the uptake of the drug into bone, where it exerts its pharmacological ... dj washington pa