Webphosphorylates β-catenin at Ser552 in vitro and in vivo. AKT-mediated phosphorylation of β-catenin causes its disassociation from cell-cell contacts and accumulation in both the cytosol and the nucleus and enhances its interaction with 14-3-3ζ via a binding motif containing Ser552. WebNov 1, 2011 · It is established however that FoxO proteins phosphorylated at the AKT sites can be detected primarily in the cytoplasm, while nuclear FoxO is devoid of phosphorylation at these sites, suggesting that even if FoxO proteins are being phosphorylated in the nucleus, their half-life in this compartment is short.
Phospho-(Ser/Thr) Kinase Substrate - Cell Signaling …
WebBy mapping all of the CK1ε phosphorylation sites on PER2, they opine that the different sites differentially target PER2 to two cellular locations—nucleus or proteasome. Both interpretations agree, however, that the tau allele is a particularly interesting mutation biochemically as it differentially affects CK1ε activity toward specific substrates. WebAug 10, 2024 · Thus, the mTORC1-controlled phosphorylation status of SCYL1 is an important determinant regulating subcellular distribution and function of endolysosomal compartments. It may also explain the... data speed monitor for windows 10
Phosphoproteome profiling uncovers a key role for CDKs …
WebApr 7, 2024 · To identify previously undiscovered substrates of ULK1 kinase activity, we generated an optimal ULK1 phosphorylation consensus motif, which uncovered … WebJun 1, 2024 · However, ATR phosphorylation sites on human CST have not been reported. The budding yeast Cdc13 can be phosphorylated on serines 225, 249, 255, … WebApr 4, 2024 · Further in-depth studies verified that PRKCI can interact with RIPK2 to promote PC growth and liver metastasis through enhancing phosphorylation of JNK, ERK and NF-κB signaling pathways. The broad phosphorylation activity of PRKCI and RIPK2 in PC pathogenesis provides candidate targets for effective intervention. data speed of at\u0026t unlimited premium