WebMay 6, 2016 · Lu Wang, Lin Lu & Heng Du Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, 5323 Harry … WebTherefore, our findings suggest that CypD-mediated mPT is a mitochondrial compensatory response to MCU-mediated excess mitochondrial calcium accumulation. Moreover, CypD may potentially modulate ...
Platelet Cyclophilin D-Dependent Events Limit Venous Thrombotic ...
WebCyclophilin D (CypD) is a specific mitochondrial protein. Recent studies have shown that F1FO ATP synthase oligomycin sensitivity conferring protein (OSCP) is a binding partner of CypD. The interaction of CypD with OSCP modulates F1FO ATP synthase function and mediates mitochondrial permeability transition pore (mPTP) opening. WebHeng Du et al. observed that CypD deficiency attenuates Aβ-induced mito-chondrial ROS production [22]. Oxidative stress would occur when scavenging activities of intracellular antioxidant and the production of highly reactive oxygen species get out of balance. Physiological level of ROS is bits and bobs sponge
Blockade of cyclophilin D rescues dexamethasone …
WebJan 21, 2024 · Conclusion: CypD stimulates mPTP excessive opening, subsequently causing endoplasmic reticulum stress through p38 mitogen-activated protein kinase activation, and results in enhanced sterol … Webfunction and added to the body of CypD-dependent mechanisms underlying Ab-induced mitochondrial and synaptic degeneration [12,29]. The goal of the present study is to determine the effect of CypD on Ab-induced axonal mitochondrial trafficking and synaptic damage. We demonstrate that the blockade of mPTP by CypD WebJun 1, 2014 · Program Director/Principal Investigator: Du, Heng Project Description/Abstract Mitochondrial dysfunction and synaptic loss are early pathological features of Alzheimer's … bits and bobs snow archive