Dichloromethane mutagenicity

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August undefined, 2024

WebDichloromethane (DCM) is a colorless liquid with a sweet, pleasant odor. The major use of DCM is as a solvent in the pharmaceutical and chemical industry for reactions, purification and isolation of intermediates or products. WebThe dichloromethane extracts of SRM 1649 and SRM 1650 contained direct-acting mutagens in Salmonella strains TA98 and TA100; SRM 1650 was significantly more potent than SRM 1649 in either strain. Addition of S9 caused a large decrease in mutagenicity of each extract, although SRM 1650 remained more potent.

Influence of GSH S-transferase on the mutagenicity induced by ... - PubMed

WebMethylene Chloride is a clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of … WebMay 17, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are ... Osamu Endo, Kazuho Inaba, Yukari Totsuka, Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane, Mutagenesis, … foals 2023

Antimutagenic activity of commercial chicken-essence against ...

WebSep 1, 1983 · The metabolic activation and mutagenicity of dichloromethane and chlorofluoromethane were investigated using rat liver fractions and Salmonella typhimurium strain TA100. Both dihalomethanes gave a mutagenic response without the addition of rat-liver fractions. This response has been shown to be due to bacterial metabolism of the … WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases Daniel Gisi, Thomas Leisinger & … WebMay 17, 2024 · Since the mutagenicity of DCM was significantly increased in TA100-GST compared with mock control (TA100-pCTC), GSTT1 is thought to be involved in the … foals 2023 tour

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WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases. The kinetic properties of bacterial … WebProduct name : Dichloromethane CAS-No. : 75-09-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 greenwich community hubWebJan 9, 2006 · Mutagenicity: mutagenic in salmonella typhimurium Ames assay : Gene mutation in hamster ovary cells (3,000 ppm) : DNA damage in mouse liver cells (400 u mol/L) OTHER DATA: Limited evidence of a carcinogenic effect. Component Carcinogenicity Dichloromethane (75-09-2) ACGIH: A3 - Confirmed animal carcinogen with unknown … foals 2022 tour

"WebNov 28, 2016 · 1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees … " - Dichloromethane mutagenicity

Dichloromethane mutagenicity

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WebMutagenicity: DNA inhibition: Human, Fibroblast = 5000 ppm/1H (Continuous).; Morphological transformation: Rat, Embryo = 160 umol/L.; DNA damage: Oral, rat = 1275 mg/kg.; ... The neurotoxicity is thought to be due to a direct nonspecific CNS depressant action of dichloromethane and to indirect effects of carbon monoxide. … WebDichloromethane is a lipophilic solvent of low relative molecular mass, which can readily cross biological membranes. Pulmonary uptake is rapid, approaching steady state within …

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WebPT.SMART-LAB INDONESIA MSDS – DICHLOROMETHANE Page 2 MATERIAL SAFETY DATA SHEET DICHLOROMETHANE Revision : 02 Date: November 3rd, 2024 MSDS Number : 068 P202 Do not handle until all safety precautions have been read and understood. P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P302 + P352 IF … WebIn vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats. In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes …

Hepatic toxicity. Hepatic effects are commonly observed forms of toxicity following inhalation (Burek et al. 1984; Nitschke et al. 1988) or oral (Serota et al. 1986a) dichloromethane exposure in rodents. Changes observed in animals following dichloromethane exposure include liver foci/areas of alteration, … See more In 2011, the Integrated Risk Information System (IRIS) of the U.S. Environmental Protection Agency (EPA) released an updated Toxicological Review of Dichloromethane (Methylene Chloride) (U.S. EPA 2011). In … See more The toxicological review was developed according to the general risk assessment guidelines (National Research Council 1983, 1994). The literature search strategy was based on the … See more In summary, the IRIS Toxicological Review of Dichloromethane (U.S. EPA 2011) developed noncancer reference dose values for oral … See more Dichloromethane metabolism occurs primarily in the liver but also in lung tissues, particularly in mice. The PBPK model structure for dichloromethane traces back to one … See more WebTheir mutagenicity was examined with Salmonella typhimurium TA98 in presence or absence of S9 mix. The total mutagenic activity of the acetone extract was 1.8-7.0-fold that of the dichloromethane extract. ... However, the amount of pyrene in the dichloromethane extract was much higher than in the acetone extract. These results indicate that the ...

WebSix chicken-essence concentrates (CEC) or their dichloromethane extracts (DECE) showed inhibition of the mutagenicity of indirect environmental mutagens such as 2-amino-3-methylimidazo[4,5- f]quinoline (IQ), 3-amino-l-methyl-5-H-pyrido[4,3-b] indole (Trp-P-2), and benzo[a]pyrene (B[a)P), but contrarily had no effect on direct environmental ... WebGerm cell mutagenicity Ames test S. typhimurium Result: negative Mutagenicity (micronucleus test) Hamster - male and female Result: negative Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No …

WebMutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). ... Methanol (90%) and dichloromethane ...

WebGerm cell mutagenicity No data available Carcinogenicity Evidence of a carcinogenic effect. IARC: 2A - Group 2A: Probably carcinogenic to humans (Dichloromethane) NTP: RAHC - Reasonably anticipated to be a human carcinogen (Dichloromethane) OSHA: OSHA specifically regulated carcinogen (Dichloromethane) Reproductive toxicity No … greenwich community safety strategyWebThe results suggest that if an interaction between DCM and GSH is required for the activation of DCM to a bacterial mutagen, it occurs at low levels of endogenous GSH and is not significantly affected by GSH supplementation. Dichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a … greenwich community tvWebDichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a bacterial mutagen. It has been suggested that the bacterial mutagenicity of DCM is mediated by glutathione (GSH) conjugation. The involvement of endogenous and exogenous GSH in the con … greenwich community college londonWebMutagenicity Genotoxicity in vivo - rat - Oral DNA damage Embryotoxicity Not Available Specific Target Organ Toxicity-single exposure ... Flammable liquids, toxic, n.o.s. (methanol and dichloromethane), 3, (6.1), pg II . Revised on 09/26/2024 Page 7 of 7 15. REGULATORY INFORMATION TSCA Inventory Status All ingredients are listed on the … foals 2022WebU.S EPA Web Server greenwich community televisionWebJan 1, 1978 · The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was … greenwich companyhttp://www.feql.wsu.edu/MSDS/Dichloromethane.pdf greenwich community television youtube