Web25 de nov. de 2024 · The PI3K/AKT/mTOR pathway has been implicated in regulating PKM2 expression levels, and evidence has indicated that rapamycin decreased PKM2 expression, highlighting the role of mTOR in regulating PKM2 (126,127). HIF-1α and c-Myc have also both been closely associated with the activity of PKM2 (128,129). WebThe mTOR (mechanistic [previously called mammalian] target of rapamycin) is an atypical serine/threonine kinase, belonging to the PIKK (phosphoinositide kinase–related kinase) family. 1 – 6 It is an evolutionarily conserved protein that plays a central role in the regulation of cellular physiology, metabolism, and stress responses. 1 – 6.

www.ncbi.nlm.nih.gov

Web1 de mar. de 2015 · HIF1α levels and HIF target gene expression were elevated in hypoxic CSC-like cells, and upregulation of AKT occurred through a mechanism involving an mTOR/S6K/IRS-1 feedback loop. Interestingly, resistance of prostate CSCs to selective mTOR inhibitors was observed because of HIF1α upregulation. Web15 de set. de 2009 · Here, we found that the inhibition of mTOR signaling up-regulated CD133 expression at both the mRNA and protein levels in a CD133-overexpressing … hidta inquiry form

HIF File Extension - What is .hif and how to open? - ReviverSoft

Web16 de jun. de 2014 · HIF-1α is potently induced by active mTOR mutants. To explore this mechanism further, we used cell line models allowing us to manipulate specific facets of mTORC1 signalling. WebHIF-1α-mediated CXCR4 activation further led to increased phosphorylation of AKT/mTOR under hypoxic conditions. Taken together, this work reports that HIF-1α promotes … Webhif-1 会促进参与细胞自主和非自主适应缺氧的数百种基因的表达。基因及其功能的例子可在图表中找到。在相应蛋白水平和 mrna 水平处，mtor 及 stat3 和 nf-kb 信号转导会使 hif … hidta fincen