WebbThe ASHP vancomycin guidelines highlight one study that looked at antimicrobial susceptibility trends across 20 years of clinical S. aureus isolates, including over 77,000 isolates that were MRSA. The researchers found that, 95.1% of isolates had an MIC of 1mg/L or below based on BMD. Webb1 jan. 2024 · So, it seems reasonable to shift from trough-only-guided dosing approach to AUC-guided dosing approach for vancomycin TDM in referral hospitals in order to maintain the therapeutic window [24, 37 ...
SHC Vancomycin Dosing Guide - Stanford University School of …
WebbShould the trough concentration of vancomycin be abandoned in therapeutic drug monitoring? A multicenter retrospective study in critically ill patients without any form of … WebbHowever, data also shows that there is a therapeutic discordance between trough and daily AUC values. A trough value of 15-20 mg/L will almost always ensure a daily AUC in excess of 400 mg*hr/L. However, the majority of patients will have daily AUCs of ≥ 600 mg*hr/L. 3 The reason why this is so concerning is that there are a growing number of ... graphic novelist brain cancer
Vancomycin Dosing & Monitoring Guide: Neonatal & Pediatric
Webb19 mars 2024 · A target AUC between 400 and 600 mg*hour/L is suggested for methicillin-resistant Staphylococcus aureus (MRSA) invasive infections in adults and pediatrics based on clinical efficacy and safety data. These AUC targets should be … Webb12 apr. 2024 · The vancomycin dose was adjusted to achieve the target AUC 400-600 mg. h/L. Results: When using the recommended regimen with initial maintenance dose (60.3%), only 36.9% of patients had AUC values in the range of 400-600 mg.h/L. After the dose adjustment, the percentage of patients reaching the PK/PD target increased to 62.5%. WebbVancomycin dosing based on AUC:MIC is now therefore recommended as the optimal dosing and monitoring method for the treatment of serious MRSA infections. Dosing by AUC:MIC (as determined by broth microdilution) with a goal of 400-600 mg-hr/Liter should keep vancomycin concentration at therapeutic levels needed to achieve a clinical … graphic novelist in utah